Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis

Objective: In the present work we studied the association of histamine receptors with second messengers during multistage carcinogenesis in Sencar mice skin. Methods: 96 Sencar female mouse, divided into six groups were used. Tumors appeared only in the 7,12-dimethyl-benz[a]anthracene-initiated and...

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Detalles Bibliográficos
Autores principales:	Fitzsimons, C., Molinari, B., Duran, H., Palmieri, M., Davio, C., Cricco, G., Bergoc, R., Rivera, E.
Formato:	JOUR
Materias:	cAMP Histamine receptors Inositol phosphates Mouse skin carcinogenesis 7,12 dimethylbenz[a]anthracene acetone cyclic amp histamine histamine agonist histamine h1 receptor histamine h2 receptor histamine receptor inositol phosphate phorbol 13 acetate 12 myristate phosphatidylinositol cimetidine cyclic AMP drug derivative histamine H1 receptor histamine H1 receptor antagonist histamine H2 receptor histamine H2 receptor antagonist mepyramine tiotidine animal cell animal experiment animal model article cellular distribution controlled study drug hydrolysis female mast cell mouse nonhuman phenotype second messenger signal transduction skin carcinogenesis tumor growth animal cell count chemically induced disorder hydrolysis metabolism pathology pathophysiology physiology skin tumor 9,10-Dimethyl-1,2-benzanthracene Animals Cell Count Cimetidine Cyclic AMP Female Histamine H1 Antagonists Histamine H2 Antagonists Hydrolysis Mast Cells Mice Phosphatidylinositols Pyrilamine Receptors, Histamine H1 Receptors, Histamine H2 Second Messenger Systems Signal Transduction Skin Neoplasms Tetradecanoylphorbol Acetate
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_10233830_v46_n8_p292_Fitzsimons
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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