Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins
Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the dise...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_10774114_v21_n2_p123_Sassetti |
| Aporte de: |
| id |
todo:paper_10774114_v21_n2_p123_Sassetti |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_10774114_v21_n2_p123_Sassetti2023-10-03T16:03:32Z Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins Sassetti, B. Vizcargüénaga, M.I. Zanaro, N.L. Silva, M.V. Kordich, L. Florentini, L. Diaz, M. Vitacco, M. Sanchez Avalos, J.C. Children Glycoproteins GPIIbIIIa HUS Platelets Uremic hemolytic syndrome fibrinogen receptor glycoprotein glycoprotein Ib glycoprotein IIb membrane protein very late activation antigen 2 article clinical article controlled study female hemolytic uremic syndrome human human cell human tissue infant male molecular dynamics pathophysiology preschool child priority journal protein expression structure activity relation thrombocyte aggregation thrombocyte count Bacterial Toxins Blood Coagulation Factors Blood Proteins Child, Preschool Diarrhea, Infantile Dysentery, Bacillary Endothelium, Vascular Escherichia coli Infections Female Hemolytic-Uremic Syndrome Humans Infant Male Microcirculation Platelet Aggregation Platelet Count Platelet Membrane Glycoproteins Shiga-Like Toxin I Spleen Thrombophilia Trihexosylceramides Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the disease were studied to understand the mechanism of platelet alteration. Patients and Methods: Coagulation parameters, platelet counts, and aggregation were studied in 49 children, and membrane glycoproteins (GPs) in 20 of the 49 children (mean age, 17 months) with HUS (Group 2) were studied during the first 4 weeks of evolution of the disease. Results: No disseminated intravascular coagulation was found in patients with recurrent or persistent thrombocytopenia. Platelet aggregation was sequentially performed during the first weeks of evolution. All patients had a functional decrease in the acute period of HUS. Platelet GPs GPIb, GPIIbIIIa, GPIIb, and GPIIIa were evaluated. GPIIbIIIa complex presented low level and never reached normal values during the first 4 weeks of disease. Conclusions: Platelet alterations are probably caused by multiple mechanisms: 'exhausted' platelets, structural membrane alterations caused by arginine-glycine- aspartic peptide blockade, or diminished or nonfunctional membrane GPIb and GPIIbIIIa complexes. Fil:Sassetti, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_10774114_v21_n2_p123_Sassetti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Children Glycoproteins GPIIbIIIa HUS Platelets Uremic hemolytic syndrome fibrinogen receptor glycoprotein glycoprotein Ib glycoprotein IIb membrane protein very late activation antigen 2 article clinical article controlled study female hemolytic uremic syndrome human human cell human tissue infant male molecular dynamics pathophysiology preschool child priority journal protein expression structure activity relation thrombocyte aggregation thrombocyte count Bacterial Toxins Blood Coagulation Factors Blood Proteins Child, Preschool Diarrhea, Infantile Dysentery, Bacillary Endothelium, Vascular Escherichia coli Infections Female Hemolytic-Uremic Syndrome Humans Infant Male Microcirculation Platelet Aggregation Platelet Count Platelet Membrane Glycoproteins Shiga-Like Toxin I Spleen Thrombophilia Trihexosylceramides |
| spellingShingle |
Children Glycoproteins GPIIbIIIa HUS Platelets Uremic hemolytic syndrome fibrinogen receptor glycoprotein glycoprotein Ib glycoprotein IIb membrane protein very late activation antigen 2 article clinical article controlled study female hemolytic uremic syndrome human human cell human tissue infant male molecular dynamics pathophysiology preschool child priority journal protein expression structure activity relation thrombocyte aggregation thrombocyte count Bacterial Toxins Blood Coagulation Factors Blood Proteins Child, Preschool Diarrhea, Infantile Dysentery, Bacillary Endothelium, Vascular Escherichia coli Infections Female Hemolytic-Uremic Syndrome Humans Infant Male Microcirculation Platelet Aggregation Platelet Count Platelet Membrane Glycoproteins Shiga-Like Toxin I Spleen Thrombophilia Trihexosylceramides Sassetti, B. Vizcargüénaga, M.I. Zanaro, N.L. Silva, M.V. Kordich, L. Florentini, L. Diaz, M. Vitacco, M. Sanchez Avalos, J.C. Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| topic_facet |
Children Glycoproteins GPIIbIIIa HUS Platelets Uremic hemolytic syndrome fibrinogen receptor glycoprotein glycoprotein Ib glycoprotein IIb membrane protein very late activation antigen 2 article clinical article controlled study female hemolytic uremic syndrome human human cell human tissue infant male molecular dynamics pathophysiology preschool child priority journal protein expression structure activity relation thrombocyte aggregation thrombocyte count Bacterial Toxins Blood Coagulation Factors Blood Proteins Child, Preschool Diarrhea, Infantile Dysentery, Bacillary Endothelium, Vascular Escherichia coli Infections Female Hemolytic-Uremic Syndrome Humans Infant Male Microcirculation Platelet Aggregation Platelet Count Platelet Membrane Glycoproteins Shiga-Like Toxin I Spleen Thrombophilia Trihexosylceramides |
| description |
Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the disease were studied to understand the mechanism of platelet alteration. Patients and Methods: Coagulation parameters, platelet counts, and aggregation were studied in 49 children, and membrane glycoproteins (GPs) in 20 of the 49 children (mean age, 17 months) with HUS (Group 2) were studied during the first 4 weeks of evolution of the disease. Results: No disseminated intravascular coagulation was found in patients with recurrent or persistent thrombocytopenia. Platelet aggregation was sequentially performed during the first weeks of evolution. All patients had a functional decrease in the acute period of HUS. Platelet GPs GPIb, GPIIbIIIa, GPIIb, and GPIIIa were evaluated. GPIIbIIIa complex presented low level and never reached normal values during the first 4 weeks of disease. Conclusions: Platelet alterations are probably caused by multiple mechanisms: 'exhausted' platelets, structural membrane alterations caused by arginine-glycine- aspartic peptide blockade, or diminished or nonfunctional membrane GPIb and GPIIbIIIa complexes. |
| format |
JOUR |
| author |
Sassetti, B. Vizcargüénaga, M.I. Zanaro, N.L. Silva, M.V. Kordich, L. Florentini, L. Diaz, M. Vitacco, M. Sanchez Avalos, J.C. |
| author_facet |
Sassetti, B. Vizcargüénaga, M.I. Zanaro, N.L. Silva, M.V. Kordich, L. Florentini, L. Diaz, M. Vitacco, M. Sanchez Avalos, J.C. |
| author_sort |
Sassetti, B. |
| title |
Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| title_short |
Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| title_full |
Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| title_fullStr |
Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| title_full_unstemmed |
Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins |
| title_sort |
hemolytic uremic syndrome in children: platelet aggregation and membrane glycoproteins |
| url |
http://hdl.handle.net/20.500.12110/paper_10774114_v21_n2_p123_Sassetti |
| work_keys_str_mv |
AT sassettib hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT vizcarguenagami hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT zanaronl hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT silvamv hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT kordichl hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT florentinil hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT diazm hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT vitaccom hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins AT sanchezavalosjc hemolyticuremicsyndromeinchildrenplateletaggregationandmembraneglycoproteins |
| _version_ |
1807317992906686464 |