Naturally-occurring cyclopeptides: Structures and bioactivity
Cyclic peptides are a special bioactive group of compounds with interesting pharmacological and biochemical properties. Different natural sources are mentioned in this paper, but interest is focused on those cyclopeptides isolated from higher plants and higher fungi. Cyclopeptides occur in higher pl...
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todo:paper_13852728_v10_n16_p2075_Pomilio2023-10-03T16:12:10Z Naturally-occurring cyclopeptides: Structures and bioactivity Pomilio, A.B. Battista, M.E. Vitale, A.A. Amanita virosa Heterocyclopeptides m-Ansa Compounds Phencyclopeptines Proline-rich Cyclic peptides antamanide colistin cycloleonurinin cyclolinopeptide A cyclolinopeptide B cyclolinopeptide C cyclolinopeptide D cyclolinopeptide K cyclopeptide cyclosporin A cyclosporin B franganine lyciumin a lyciumin b mahafacyclin A mahafacyclin B mauritine c omphalotin A penicillin derivative plant extract polymyxin B pseudostellarin A pseudostellarin G sativanine A scutianine A scutianine B scutianine C scutianine D scutianine E unclassified drug unindexed drug ab initio calculation cyclization drug classification drug conformation drug determination drug hydrolysis drug mechanism drug structure electrospray mass spectrometry human hydrogen bond hydrophobicity ion cyclotron resonance mass spectrometry liver toxicity matrix assisted laser desorption ionization time of flight mass spectrometry molecular dynamics nonhuman nuclear magnetic resonance spectroscopy plant pathogen interaction protein determination protein structure proton nuclear magnetic resonance review treatment indication X ray crystallography Cyclic peptides are a special bioactive group of compounds with interesting pharmacological and biochemical properties. Different natural sources are mentioned in this paper, but interest is focused on those cyclopeptides isolated from higher plants and higher fungi. Cyclopeptides occur in higher plant species, which belong to the following families: Annonaceae, Araliaceae, Asteraceae, Caryophyllaceae, Euphorbiaceae, Fabaceae, Labiatac, Linaceae, Olacaceae, Rhamnaceae, Rubiaceae, Rutaceae, Schizandraceae, Solanaceae, and Violaceae. Basidiomycetes is the group of higher fungi, which has shown to be rich in cyclopeptides, e.g., Amanita, Conocybe, Lepiota, Galerina, and Omphalotus species. Usually these compounds are associated to a toxic response in mammals, as well as to cytotoxic, insecticidal, antimalarial, estrogenic, sedative, nematicidal, antimicrobial, immunosuppressive, and enzyme-inhibitory activities. Structures are elucidated by chemical methods and spectroscopic techniques. Configurational and conformational analyses of some bioactive cyclopeptides are discussed. Conformational studies of the natural cyclopeptides and their derivatives are related to the stereochemical requirements for these bioactive compounds. © 2006 Bentham Science Publishers Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_13852728_v10_n16_p2075_Pomilio |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amanita virosa Heterocyclopeptides m-Ansa Compounds Phencyclopeptines Proline-rich Cyclic peptides antamanide colistin cycloleonurinin cyclolinopeptide A cyclolinopeptide B cyclolinopeptide C cyclolinopeptide D cyclolinopeptide K cyclopeptide cyclosporin A cyclosporin B franganine lyciumin a lyciumin b mahafacyclin A mahafacyclin B mauritine c omphalotin A penicillin derivative plant extract polymyxin B pseudostellarin A pseudostellarin G sativanine A scutianine A scutianine B scutianine C scutianine D scutianine E unclassified drug unindexed drug ab initio calculation cyclization drug classification drug conformation drug determination drug hydrolysis drug mechanism drug structure electrospray mass spectrometry human hydrogen bond hydrophobicity ion cyclotron resonance mass spectrometry liver toxicity matrix assisted laser desorption ionization time of flight mass spectrometry molecular dynamics nonhuman nuclear magnetic resonance spectroscopy plant pathogen interaction protein determination protein structure proton nuclear magnetic resonance review treatment indication X ray crystallography |
| spellingShingle |
Amanita virosa Heterocyclopeptides m-Ansa Compounds Phencyclopeptines Proline-rich Cyclic peptides antamanide colistin cycloleonurinin cyclolinopeptide A cyclolinopeptide B cyclolinopeptide C cyclolinopeptide D cyclolinopeptide K cyclopeptide cyclosporin A cyclosporin B franganine lyciumin a lyciumin b mahafacyclin A mahafacyclin B mauritine c omphalotin A penicillin derivative plant extract polymyxin B pseudostellarin A pseudostellarin G sativanine A scutianine A scutianine B scutianine C scutianine D scutianine E unclassified drug unindexed drug ab initio calculation cyclization drug classification drug conformation drug determination drug hydrolysis drug mechanism drug structure electrospray mass spectrometry human hydrogen bond hydrophobicity ion cyclotron resonance mass spectrometry liver toxicity matrix assisted laser desorption ionization time of flight mass spectrometry molecular dynamics nonhuman nuclear magnetic resonance spectroscopy plant pathogen interaction protein determination protein structure proton nuclear magnetic resonance review treatment indication X ray crystallography Pomilio, A.B. Battista, M.E. Vitale, A.A. Naturally-occurring cyclopeptides: Structures and bioactivity |
| topic_facet |
Amanita virosa Heterocyclopeptides m-Ansa Compounds Phencyclopeptines Proline-rich Cyclic peptides antamanide colistin cycloleonurinin cyclolinopeptide A cyclolinopeptide B cyclolinopeptide C cyclolinopeptide D cyclolinopeptide K cyclopeptide cyclosporin A cyclosporin B franganine lyciumin a lyciumin b mahafacyclin A mahafacyclin B mauritine c omphalotin A penicillin derivative plant extract polymyxin B pseudostellarin A pseudostellarin G sativanine A scutianine A scutianine B scutianine C scutianine D scutianine E unclassified drug unindexed drug ab initio calculation cyclization drug classification drug conformation drug determination drug hydrolysis drug mechanism drug structure electrospray mass spectrometry human hydrogen bond hydrophobicity ion cyclotron resonance mass spectrometry liver toxicity matrix assisted laser desorption ionization time of flight mass spectrometry molecular dynamics nonhuman nuclear magnetic resonance spectroscopy plant pathogen interaction protein determination protein structure proton nuclear magnetic resonance review treatment indication X ray crystallography |
| description |
Cyclic peptides are a special bioactive group of compounds with interesting pharmacological and biochemical properties. Different natural sources are mentioned in this paper, but interest is focused on those cyclopeptides isolated from higher plants and higher fungi. Cyclopeptides occur in higher plant species, which belong to the following families: Annonaceae, Araliaceae, Asteraceae, Caryophyllaceae, Euphorbiaceae, Fabaceae, Labiatac, Linaceae, Olacaceae, Rhamnaceae, Rubiaceae, Rutaceae, Schizandraceae, Solanaceae, and Violaceae. Basidiomycetes is the group of higher fungi, which has shown to be rich in cyclopeptides, e.g., Amanita, Conocybe, Lepiota, Galerina, and Omphalotus species. Usually these compounds are associated to a toxic response in mammals, as well as to cytotoxic, insecticidal, antimalarial, estrogenic, sedative, nematicidal, antimicrobial, immunosuppressive, and enzyme-inhibitory activities. Structures are elucidated by chemical methods and spectroscopic techniques. Configurational and conformational analyses of some bioactive cyclopeptides are discussed. Conformational studies of the natural cyclopeptides and their derivatives are related to the stereochemical requirements for these bioactive compounds. © 2006 Bentham Science Publishers Ltd. |
| format |
JOUR |
| author |
Pomilio, A.B. Battista, M.E. Vitale, A.A. |
| author_facet |
Pomilio, A.B. Battista, M.E. Vitale, A.A. |
| author_sort |
Pomilio, A.B. |
| title |
Naturally-occurring cyclopeptides: Structures and bioactivity |
| title_short |
Naturally-occurring cyclopeptides: Structures and bioactivity |
| title_full |
Naturally-occurring cyclopeptides: Structures and bioactivity |
| title_fullStr |
Naturally-occurring cyclopeptides: Structures and bioactivity |
| title_full_unstemmed |
Naturally-occurring cyclopeptides: Structures and bioactivity |
| title_sort |
naturally-occurring cyclopeptides: structures and bioactivity |
| url |
http://hdl.handle.net/20.500.12110/paper_13852728_v10_n16_p2075_Pomilio |
| work_keys_str_mv |
AT pomilioab naturallyoccurringcyclopeptidesstructuresandbioactivity AT battistame naturallyoccurringcyclopeptidesstructuresandbioactivity AT vitaleaa naturallyoccurringcyclopeptidesstructuresandbioactivity |
| _version_ |
1807323424657244160 |