Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry

Naturally occurring terpenes were combined by click reactions to generate sixteen hybrid molecules. The diterpene imbricatolic acid (IA) containing an azide group was used as starting compound for the synthesis of all the derivatives. The alkyne group in the terpenes cyperenoic acid, dehydroabietino...

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Detalles Bibliográficos
Autores principales: Pertino, M.W., Petrera, E., Edith Alché, L., Schmeda-Hirschmann, G.
Formato: JOUR
Materias:
Antiviral
Click chemistry
Cytotoxicity
Hybrid molecules
Terpenes
antineoplastic agent
antivirus agent
terpene
animal
carbon nuclear magnetic resonance
chemistry
click chemistry
drug effect
drug screening
electrospray mass spectrometry
human
Human alphaherpesvirus 1
mouse
preclinical study
proton nuclear magnetic resonance
RAW 264.7 cell line
synthesis
tumor cell line
Animals
Antineoplastic Agents
Antiviral Agents
Carbon-13 Magnetic Resonance Spectroscopy
Cell Line, Tumor
Click Chemistry
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
Herpesvirus 1, Human
Humans
Mice
Proton Magnetic Resonance Spectroscopy
RAW 264.7 Cells
Spectrometry, Mass, Electrospray Ionization
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14203049_v23_n6_p_Pertino
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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