Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets
Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity...
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todo:paper_14726483_v31_n5_p655_Bazzano2023-10-03T16:17:56Z Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets Bazzano, M.V. Torelli, C. Pustovrh, M.C. Paz, D.A. Elia, E.M. anti-Müllerian hormone fertility follicular cyst folliculogenesis C reactive protein cholesterol cyclooxygenase 2 estradiol Muellerian inhibiting factor triacylglycerol cholesterol cyclooxygenase 2 Muellerian inhibiting factor triacylglycerol animal experiment Article cafeteria diet cholesterol blood level controlled study diet diet induced obesity estradiol blood level estrus cycle female female fertility follicle cyst hyperglycemia immunoreactivity nonhuman obesity ovarian reserve ovary function pregnancy rat triacylglycerol blood level adverse effects animal blood complication Infertility, Female metabolism obesity ovary Western diet Wistar rat Animals Anti-Mullerian Hormone Cholesterol Cyclooxygenase 2 Diet, Western Female Hyperglycemia Infertility, Female Obesity Ovary Pregnancy Rats Rats, Wistar Triglycerides Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Müllerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals. © 2015 Reproductive Healthcare Ltd. Fil:Pustovrh, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paz, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Elia, E.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14726483_v31_n5_p655_Bazzano |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
anti-Müllerian hormone fertility follicular cyst folliculogenesis C reactive protein cholesterol cyclooxygenase 2 estradiol Muellerian inhibiting factor triacylglycerol cholesterol cyclooxygenase 2 Muellerian inhibiting factor triacylglycerol animal experiment Article cafeteria diet cholesterol blood level controlled study diet diet induced obesity estradiol blood level estrus cycle female female fertility follicle cyst hyperglycemia immunoreactivity nonhuman obesity ovarian reserve ovary function pregnancy rat triacylglycerol blood level adverse effects animal blood complication Infertility, Female metabolism obesity ovary Western diet Wistar rat Animals Anti-Mullerian Hormone Cholesterol Cyclooxygenase 2 Diet, Western Female Hyperglycemia Infertility, Female Obesity Ovary Pregnancy Rats Rats, Wistar Triglycerides |
| spellingShingle |
anti-Müllerian hormone fertility follicular cyst folliculogenesis C reactive protein cholesterol cyclooxygenase 2 estradiol Muellerian inhibiting factor triacylglycerol cholesterol cyclooxygenase 2 Muellerian inhibiting factor triacylglycerol animal experiment Article cafeteria diet cholesterol blood level controlled study diet diet induced obesity estradiol blood level estrus cycle female female fertility follicle cyst hyperglycemia immunoreactivity nonhuman obesity ovarian reserve ovary function pregnancy rat triacylglycerol blood level adverse effects animal blood complication Infertility, Female metabolism obesity ovary Western diet Wistar rat Animals Anti-Mullerian Hormone Cholesterol Cyclooxygenase 2 Diet, Western Female Hyperglycemia Infertility, Female Obesity Ovary Pregnancy Rats Rats, Wistar Triglycerides Bazzano, M.V. Torelli, C. Pustovrh, M.C. Paz, D.A. Elia, E.M. Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| topic_facet |
anti-Müllerian hormone fertility follicular cyst folliculogenesis C reactive protein cholesterol cyclooxygenase 2 estradiol Muellerian inhibiting factor triacylglycerol cholesterol cyclooxygenase 2 Muellerian inhibiting factor triacylglycerol animal experiment Article cafeteria diet cholesterol blood level controlled study diet diet induced obesity estradiol blood level estrus cycle female female fertility follicle cyst hyperglycemia immunoreactivity nonhuman obesity ovarian reserve ovary function pregnancy rat triacylglycerol blood level adverse effects animal blood complication Infertility, Female metabolism obesity ovary Western diet Wistar rat Animals Anti-Mullerian Hormone Cholesterol Cyclooxygenase 2 Diet, Western Female Hyperglycemia Infertility, Female Obesity Ovary Pregnancy Rats Rats, Wistar Triglycerides |
| description |
Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Müllerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals. © 2015 Reproductive Healthcare Ltd. |
| format |
JOUR |
| author |
Bazzano, M.V. Torelli, C. Pustovrh, M.C. Paz, D.A. Elia, E.M. |
| author_facet |
Bazzano, M.V. Torelli, C. Pustovrh, M.C. Paz, D.A. Elia, E.M. |
| author_sort |
Bazzano, M.V. |
| title |
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| title_short |
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| title_full |
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| title_fullStr |
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| title_full_unstemmed |
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| title_sort |
obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets |
| url |
http://hdl.handle.net/20.500.12110/paper_14726483_v31_n5_p655_Bazzano |
| work_keys_str_mv |
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