Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus

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A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemi...

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Autores principales:	Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S.
Formato:	JOUR
Materias:	antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14786419_v28_n4_p213_Careaga
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_14786419_v28_n4_p213_Careaga
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spelling	todo:paper_14786419_v28_n4_p213_Careaga2023-10-03T16:19:28Z Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus Careaga, V.P. Bueno, C. Muniain, C. Alché, L. Maier, M.S. antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2013 Taylor & Francis. Fil:Careaga, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bueno, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14786419_v28_n4_p213_Careaga
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes
spellingShingle	antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes Careaga, V.P. Bueno, C. Muniain, C. Alché, L. Maier, M.S. Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
topic_facet	antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes
description	A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2013 Taylor & Francis.
format	JOUR
author	Careaga, V.P. Bueno, C. Muniain, C. Alché, L. Maier, M.S.
author_facet	Careaga, V.P. Bueno, C. Muniain, C. Alché, L. Maier, M.S.
author_sort	Careaga, V.P.
title	Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_short	Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_full	Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_fullStr	Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_full_unstemmed	Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_sort	pseudocnoside a, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber pseudocnus dubiosus leoninus
url	http://hdl.handle.net/20.500.12110/paper_14786419_v28_n4_p213_Careaga
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Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus

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