Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus

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A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemi...

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Autores principales: Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S.
Formato: INPR
Lenguaje:English
Materias:
antiproliferative
cytotoxic
Pseudocnus dubiosus leoninus
sulphated triterpene glycosides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14786419_v_n_p_Careaga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_14786419_v_n_p_Careaga
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spelling todo:paper_14786419_v_n_p_Careaga2023-10-03T16:19:28Z Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus Careaga, V.P. Bueno, C. Muniain, C. Alché, L. Maier, M.S. antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2012 Copyright Taylor and Francis Group, LLC. Fil:Careaga, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bueno, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14786419_v_n_p_Careaga
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic antiproliferative
cytotoxic
Pseudocnus dubiosus leoninus
sulphated triterpene glycosides
spellingShingle antiproliferative
cytotoxic
Pseudocnus dubiosus leoninus
sulphated triterpene glycosides
Careaga, V.P.
Bueno, C.
Muniain, C.
Alché, L.
Maier, M.S.
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
topic_facet antiproliferative
cytotoxic
Pseudocnus dubiosus leoninus
sulphated triterpene glycosides
description A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2012 Copyright Taylor and Francis Group, LLC.
format INPR
author Careaga, V.P.
Bueno, C.
Muniain, C.
Alché, L.
Maier, M.S.
author_facet Careaga, V.P.
Bueno, C.
Muniain, C.
Alché, L.
Maier, M.S.
author_sort Careaga, V.P.
title Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_short Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_full Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_fullStr Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_full_unstemmed Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
title_sort pseudocnoside a, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber pseudocnus dubiosus leoninus
url http://hdl.handle.net/20.500.12110/paper_14786419_v_n_p_Careaga
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AT buenoc pseudocnosideaanewcytotoxicandantiproliferativetriterpeneglycosidefromtheseacucumberpseudocnusdubiosusleoninus
AT muniainc pseudocnosideaanewcytotoxicandantiproliferativetriterpeneglycosidefromtheseacucumberpseudocnusdubiosusleoninus
AT alchel pseudocnosideaanewcytotoxicandantiproliferativetriterpeneglycosidefromtheseacucumberpseudocnusdubiosusleoninus
AT maierms pseudocnosideaanewcytotoxicandantiproliferativetriterpeneglycosidefromtheseacucumberpseudocnusdubiosusleoninus
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