Chemistry and bioactivity of withanolides from south american Solanaceae

Since the isolation of withaferin A in 1965 over 300 withanolides have been described, largely from genera belonging to the Solanaceae. Although until the mid eighties most of the withanolides appeared to adhere to the basic structure of withaferin A, nowadays a considerable number of withanolides a...

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Autores principales:	Veleiro, A.S., Oberti, J.C., Burton, G.
Formato:	SER
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15725995_v32_nPARTL_p1019_Veleiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_15725995_v32_nPARTL_p1019_Veleiro2023-10-03T16:27:22Z Chemistry and bioactivity of withanolides from south american Solanaceae Veleiro, A.S. Oberti, J.C. Burton, G. Since the isolation of withaferin A in 1965 over 300 withanolides have been described, largely from genera belonging to the Solanaceae. Although until the mid eighties most of the withanolides appeared to adhere to the basic structure of withaferin A, nowadays a considerable number of withanolides and withanolide related compounds are known, which present modified skeletons, aromatic rings, additional rings, etc., posing challenging problems of structure elucidation. Many of these structures coexist in the plants with "normal" withanolides and thus allow us to infer the biogenetic relationships among them and the transformations they suffer in the plant. As a further bonus, several species show marked seasonal and geographical variations in the amount and type of withanolides present, thus adding to the structural diversity. The latter is particularly noteworthy in (but not restricted to) species of the Jaborosa and Salpichroa genera. In recent years these genera, both native to South America, have rendered several novel withanolide types. Exodeconus, Dunalia, Deprea and Vassobia are other southamerican genera where unusual structures have also been found. Recently, some of the withanolides isolated from these plants have shown interesting biological activities as cancer chemopreventive agents (inductors of quinone reductase), as feeding deterrants for several insects, and displaying selective phytotoxicity towards monocotiledoneous and dicotiledoneous species. Trypanocidal and leishmanicidal activities have also been reported. © 2005 Elsevier B.V. All rights reserved. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. SER info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15725995_v32_nPARTL_p1019_Veleiro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description	Since the isolation of withaferin A in 1965 over 300 withanolides have been described, largely from genera belonging to the Solanaceae. Although until the mid eighties most of the withanolides appeared to adhere to the basic structure of withaferin A, nowadays a considerable number of withanolides and withanolide related compounds are known, which present modified skeletons, aromatic rings, additional rings, etc., posing challenging problems of structure elucidation. Many of these structures coexist in the plants with "normal" withanolides and thus allow us to infer the biogenetic relationships among them and the transformations they suffer in the plant. As a further bonus, several species show marked seasonal and geographical variations in the amount and type of withanolides present, thus adding to the structural diversity. The latter is particularly noteworthy in (but not restricted to) species of the Jaborosa and Salpichroa genera. In recent years these genera, both native to South America, have rendered several novel withanolide types. Exodeconus, Dunalia, Deprea and Vassobia are other southamerican genera where unusual structures have also been found. Recently, some of the withanolides isolated from these plants have shown interesting biological activities as cancer chemopreventive agents (inductors of quinone reductase), as feeding deterrants for several insects, and displaying selective phytotoxicity towards monocotiledoneous and dicotiledoneous species. Trypanocidal and leishmanicidal activities have also been reported. © 2005 Elsevier B.V. All rights reserved.
format	SER
author	Veleiro, A.S. Oberti, J.C. Burton, G.
spellingShingle	Veleiro, A.S. Oberti, J.C. Burton, G. Chemistry and bioactivity of withanolides from south american Solanaceae
author_facet	Veleiro, A.S. Oberti, J.C. Burton, G.
author_sort	Veleiro, A.S.
title	Chemistry and bioactivity of withanolides from south american Solanaceae
title_short	Chemistry and bioactivity of withanolides from south american Solanaceae
title_full	Chemistry and bioactivity of withanolides from south american Solanaceae
title_fullStr	Chemistry and bioactivity of withanolides from south american Solanaceae
title_full_unstemmed	Chemistry and bioactivity of withanolides from south american Solanaceae
title_sort	chemistry and bioactivity of withanolides from south american solanaceae
url	http://hdl.handle.net/20.500.12110/paper_15725995_v32_nPARTL_p1019_Veleiro
work_keys_str_mv	AT veleiroas chemistryandbioactivityofwithanolidesfromsouthamericansolanaceae AT obertijc chemistryandbioactivityofwithanolidesfromsouthamericansolanaceae AT burtong chemistryandbioactivityofwithanolidesfromsouthamericansolanaceae
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Chemistry and bioactivity of withanolides from south american Solanaceae

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