HEp-2 cell line as an experimental model to evaluate genotoxic effects of pentavalent inorganic arsenic

Early detection of toxic events induced by xenobiotics is necessary for a proper assessment of human risk after the exposure to those agents. The aim of this work was to evaluate the cell line HEp-2 as an experimental model to determine the genotoxic effects of sodium arsenate. To this end, we deter...

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Detalles Bibliográficos
Autores principales: Andrioli, N.B., Chaufan, G., Coalova, I., Ríos De Molina, M.C., Mudry, M.D.
Formato: JOUR
Materias:
Cytotoxicity
Genotoxicity
Glutathione
HEp-2 cell line
arsenate sodium
glutathione
glutathione transferase
Article
chromosome aberration
concentration (parameters)
controlled study
cytotoxicity
enzyme activity
evaluation study
experimental model
genotoxicity
human
human cell
LC50
lowest observed effect concentration
micronucleus
micronucleus test
MTT assay
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16660390_v28_n2_p15_Andrioli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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