Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons

Leptin is an adipose-derived hormone that controls appetite and energy expenditure. Leptin receptors are expressed on extra-hypothalamic ventrobasal (VB) and reticular thalamic (RTN) nuclei from embryonic stages. Here, we studied the effects of pressure-puff, local application of leptin on both syna...

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Detalles Bibliográficos
Autores principales:	Perissinotti, P.P., Rivero-Echeto, M.C., Garcia-Rill, E., Bisagno, V., Urbano, F.J.
Formato:	JOUR
Materias:	GABA Leptin Mouse ob/ob Thalamic reticular nucleus 4 aminobutyric acid calcium activated potassium channel glutamic acid Janus kinase 2 leptin recombinant leptin 6 cyano 7 nitro 2,3 quinoxalinedione alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide amino acid receptor blocking agent enzyme inhibitor Jak2 protein, mouse sodium channel blocking agent tetrodotoxin tyrphostin 4 aminobutyric acid release action potential animal experiment animal tissue Article brain slice controlled study GABAergic transmission glutamatergic synapse male mouse nerve excitability neuromodulation nonhuman obesity priority journal synaptic transmission thalamus reticular nucleus thalamus ventral nucleus whole cell patch clamp animal body temperature C57BL mouse cytology deficiency drug effect genetics metabolism nerve cell physiology signal transduction synaptic potential thalamus nucleus transgenic mouse 6-Cyano-7-nitroquinoxaline-2,3-dione Action Potentials Animals Body Temperature Enzyme Inhibitors Excitatory Amino Acid Antagonists gamma-Aminobutyric Acid Janus Kinase 2 Male Mice Mice, Inbred C57BL Mice, Transgenic Neurons Signal Transduction Sodium Channel Blockers Synaptic Potentials Synaptic Transmission Tetrodotoxin Thalamic Nuclei Tyrphostins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_18632653_v223_n5_p2499_Perissinotti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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