Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina
Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the r...
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todo:paper_19326203_v13_n1_p_Badano2023-10-03T16:34:54Z Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina Badano, I. Sanabria, D.J. Totaro, M.E. Rubinstein, S. Gili, J.A. Liotta, D.J. Picconi, M.A. Campos, R.H. Schurr, T.G. mitochondrial DNA mitochondrial DNA adult African aged American Indian ancestry group Argentina Article cancer risk controlled study European female genetic risk human Human papillomavirus type 16 Human papillomavirus type 58 major clinical study nonhuman nucleotide sequence papillomavirus infection retrospective study risk factor uterine cervix cancer very elderly complication ethnic group ethnology genetics haplotype multivariate analysis papillomavirus infection pathology uterine cervix tumor Adult Argentina DNA, Mitochondrial Ethnic Groups Female Haplotypes Humans Multivariate Analysis Papillomavirus Infections Uterine Cervical Neoplasms Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province. Methods Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed. mtDNA ancestry was assessed through HVS1 sequencing, while the detection and typing of HPV infection was conducted through nested multiplex PCR analysis. Multivariate logistic regression was conducted with the resulting data to estimate the odds ratios (ORs) adjusted by socio-demographic variables. Results The study participants showed 68.6% Amerindian, 26.1% European and 5.3% African mtDNA ancestry, respectively. Multiple regression analysis showed that women with African mtDNAs were three times more likely to develop a cervical lesion than those with Native American or European mtDNAs [OR of 3.8 (1.2–11.5) for ancestry and OR of 3.5 (1.0–12.0) for L haplogroups], although the associated p values were not significant when tested under more complex multivariate models. HPV infection and the development of cervical lesions/ cancer were significant for all tested models, with the highest OR values for HPV16 [OR of 24.2 (9.3–62.7)] and HPV-58 [OR of 19.0 (2.4–147.7)]. Conclusion HPV infection remains a central risk factor for cervical cancer in the Posadas population. The potential role of African mtDNA ancestry opens a new avenue for future medical association studies in multiethnic populations, and will require further confirmation in large-scale studies. © 2018 Badano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v13_n1_p_Badano |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
mitochondrial DNA mitochondrial DNA adult African aged American Indian ancestry group Argentina Article cancer risk controlled study European female genetic risk human Human papillomavirus type 16 Human papillomavirus type 58 major clinical study nonhuman nucleotide sequence papillomavirus infection retrospective study risk factor uterine cervix cancer very elderly complication ethnic group ethnology genetics haplotype multivariate analysis papillomavirus infection pathology uterine cervix tumor Adult Argentina DNA, Mitochondrial Ethnic Groups Female Haplotypes Humans Multivariate Analysis Papillomavirus Infections Uterine Cervical Neoplasms |
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mitochondrial DNA mitochondrial DNA adult African aged American Indian ancestry group Argentina Article cancer risk controlled study European female genetic risk human Human papillomavirus type 16 Human papillomavirus type 58 major clinical study nonhuman nucleotide sequence papillomavirus infection retrospective study risk factor uterine cervix cancer very elderly complication ethnic group ethnology genetics haplotype multivariate analysis papillomavirus infection pathology uterine cervix tumor Adult Argentina DNA, Mitochondrial Ethnic Groups Female Haplotypes Humans Multivariate Analysis Papillomavirus Infections Uterine Cervical Neoplasms Badano, I. Sanabria, D.J. Totaro, M.E. Rubinstein, S. Gili, J.A. Liotta, D.J. Picconi, M.A. Campos, R.H. Schurr, T.G. Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| topic_facet |
mitochondrial DNA mitochondrial DNA adult African aged American Indian ancestry group Argentina Article cancer risk controlled study European female genetic risk human Human papillomavirus type 16 Human papillomavirus type 58 major clinical study nonhuman nucleotide sequence papillomavirus infection retrospective study risk factor uterine cervix cancer very elderly complication ethnic group ethnology genetics haplotype multivariate analysis papillomavirus infection pathology uterine cervix tumor Adult Argentina DNA, Mitochondrial Ethnic Groups Female Haplotypes Humans Multivariate Analysis Papillomavirus Infections Uterine Cervical Neoplasms |
| description |
Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province. Methods Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed. mtDNA ancestry was assessed through HVS1 sequencing, while the detection and typing of HPV infection was conducted through nested multiplex PCR analysis. Multivariate logistic regression was conducted with the resulting data to estimate the odds ratios (ORs) adjusted by socio-demographic variables. Results The study participants showed 68.6% Amerindian, 26.1% European and 5.3% African mtDNA ancestry, respectively. Multiple regression analysis showed that women with African mtDNAs were three times more likely to develop a cervical lesion than those with Native American or European mtDNAs [OR of 3.8 (1.2–11.5) for ancestry and OR of 3.5 (1.0–12.0) for L haplogroups], although the associated p values were not significant when tested under more complex multivariate models. HPV infection and the development of cervical lesions/ cancer were significant for all tested models, with the highest OR values for HPV16 [OR of 24.2 (9.3–62.7)] and HPV-58 [OR of 19.0 (2.4–147.7)]. Conclusion HPV infection remains a central risk factor for cervical cancer in the Posadas population. The potential role of African mtDNA ancestry opens a new avenue for future medical association studies in multiethnic populations, and will require further confirmation in large-scale studies. © 2018 Badano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| format |
JOUR |
| author |
Badano, I. Sanabria, D.J. Totaro, M.E. Rubinstein, S. Gili, J.A. Liotta, D.J. Picconi, M.A. Campos, R.H. Schurr, T.G. |
| author_facet |
Badano, I. Sanabria, D.J. Totaro, M.E. Rubinstein, S. Gili, J.A. Liotta, D.J. Picconi, M.A. Campos, R.H. Schurr, T.G. |
| author_sort |
Badano, I. |
| title |
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| title_short |
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| title_full |
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| title_fullStr |
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| title_full_unstemmed |
Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina |
| title_sort |
mitochondrial dna ancestry, hpv infection and the risk of cervical cancer in a multiethnic population of northeastern argentina |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v13_n1_p_Badano |
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