Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation
Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the re...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19336918_v10_n1-2_p197_Ramhorst |
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todo:paper_19336918_v10_n1-2_p197_Ramhorst2023-10-03T16:36:11Z Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation Ramhorst, R. Grasso, E. Paparini, D. Hauk, V. Gallino, L. Calo, G. Vota, D. Pérez Leirós, C. chemokines maternal tolerance pregnancy chemokine stromal cell derived factor 1 chemokine adaptive immunity angiogenesis cell migration extracellular matrix homeostasis and regulation human implantation leukocyte nonhuman pregnancy protein expression Review trophoblast wound healing animal cell motion cytology decidua female leukocyte metabolism nidation trophoblast Animals Cell Movement Chemokines Decidua Embryo Implantation Female Humans Leukocytes Pregnancy Trophoblasts Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the recruitment of different leukocyte populations to generate the maternal-placental interface, but also constitutes an additional checkpoint for tissue homeostasis maintenance. The normal switch from a pro-inflammatory to an anti-inflammatory predominant microenvironment characteristic of the post-implantation stage requires redundant immune tolerance circuits triggered by key master regulators. In this review we will focus on the recruitment and conditioning of maternal immune cells to the uterus at the early implantation period with special interest on high plasticity macrophages and dendritic cells and their ability to induce regulatory T cells. We will also point to putative immunomodulatory polypeptides involved in immune homeostasis maintenance at the maternal-placental interface. © 2016 Taylor & Francis Group, LLC. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19336918_v10_n1-2_p197_Ramhorst |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
chemokines maternal tolerance pregnancy chemokine stromal cell derived factor 1 chemokine adaptive immunity angiogenesis cell migration extracellular matrix homeostasis and regulation human implantation leukocyte nonhuman pregnancy protein expression Review trophoblast wound healing animal cell motion cytology decidua female leukocyte metabolism nidation trophoblast Animals Cell Movement Chemokines Decidua Embryo Implantation Female Humans Leukocytes Pregnancy Trophoblasts |
| spellingShingle |
chemokines maternal tolerance pregnancy chemokine stromal cell derived factor 1 chemokine adaptive immunity angiogenesis cell migration extracellular matrix homeostasis and regulation human implantation leukocyte nonhuman pregnancy protein expression Review trophoblast wound healing animal cell motion cytology decidua female leukocyte metabolism nidation trophoblast Animals Cell Movement Chemokines Decidua Embryo Implantation Female Humans Leukocytes Pregnancy Trophoblasts Ramhorst, R. Grasso, E. Paparini, D. Hauk, V. Gallino, L. Calo, G. Vota, D. Pérez Leirós, C. Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| topic_facet |
chemokines maternal tolerance pregnancy chemokine stromal cell derived factor 1 chemokine adaptive immunity angiogenesis cell migration extracellular matrix homeostasis and regulation human implantation leukocyte nonhuman pregnancy protein expression Review trophoblast wound healing animal cell motion cytology decidua female leukocyte metabolism nidation trophoblast Animals Cell Movement Chemokines Decidua Embryo Implantation Female Humans Leukocytes Pregnancy Trophoblasts |
| description |
Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the recruitment of different leukocyte populations to generate the maternal-placental interface, but also constitutes an additional checkpoint for tissue homeostasis maintenance. The normal switch from a pro-inflammatory to an anti-inflammatory predominant microenvironment characteristic of the post-implantation stage requires redundant immune tolerance circuits triggered by key master regulators. In this review we will focus on the recruitment and conditioning of maternal immune cells to the uterus at the early implantation period with special interest on high plasticity macrophages and dendritic cells and their ability to induce regulatory T cells. We will also point to putative immunomodulatory polypeptides involved in immune homeostasis maintenance at the maternal-placental interface. © 2016 Taylor & Francis Group, LLC. |
| format |
JOUR |
| author |
Ramhorst, R. Grasso, E. Paparini, D. Hauk, V. Gallino, L. Calo, G. Vota, D. Pérez Leirós, C. |
| author_facet |
Ramhorst, R. Grasso, E. Paparini, D. Hauk, V. Gallino, L. Calo, G. Vota, D. Pérez Leirós, C. |
| author_sort |
Ramhorst, R. |
| title |
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| title_short |
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| title_full |
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| title_fullStr |
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| title_full_unstemmed |
Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| title_sort |
decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation |
| url |
http://hdl.handle.net/20.500.12110/paper_19336918_v10_n1-2_p197_Ramhorst |
| work_keys_str_mv |
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| _version_ |
1807315094832414720 |