Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus

Mostrar todas las versiones(2)

A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S.
Formato: INPR
Lenguaje:English
Materias:
antiproliferative
cytotoxic
Pseudocnus dubiosus leoninus
sulphated triterpene glycosides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_14786419_v_n_p_Careaga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2012 Copyright Taylor and Francis Group, LLC.

Ejemplares similares